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Product Information:

ARQ 531

ARQ 531 (Nemtabrutinib) is a reversible non-covalent inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

Cat. No.: EX-A2727    Purity: >99%
ARQ
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg485In-stock
100mg735In-stock
200mg985In-stock
1g1685In-stock
5g5350In-stock
10g8750In-stock


SynonymsNemtabrutinib
Synonyms 2ARQ-531
CAS No.2095393-15-8
Purity>99%
FormulaC25H23ClN4O4
Mol Weight478.928
Appearancewhite to off-white powder
SolubilityDMSO >50mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. S Eathiraj, et al. Targeting Ibrutinib-Resistant BTK-C481S Mutation with ARQ 531, a Reversible Non-Covalent Inhibitor of BTK. Clinical Lymphoma Myeloma & Leukemia, 2016, 16: S47-S48.
CoACoA of ARQ 531
Smiles:OC[C@@H]1CC[C@H](CO1)NC1=C2C(NC=C2C(=O)C2=C(Cl)C=C(OC3=CC=CC=C3)C=C2)=NC=N1

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