AZD-1390

AZD1390 is a potent and selective inhibitor of ATM in cells (IC50 = 0.78 nM) with the ability to cross the blood-brain barrier. AZD1390 has >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. AZD1390 displays excellent oral bioavailability in preclinical species (66% in rat and 74% in dog), is not a substrate for human efflux transporters, and has been shown to efficiently cross the BBB in non-human primate PET studies.


Cat. No.: EX-A2670	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	600	In-stock
250mg	985	In-stock
1g	1885	In-stock
5g	5650	In-stock
10g	7950	In-stock

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CAS No.	2089288-03-7
Purity	>98%
Formula	C27H32FN5O2
Mol Weight	477.5737
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

CoA	CoA of AZD-1390

Smiles:	CC(C)N1C(=O)N(C)C2=C1C1=CC(C3=CC=C(OCCCN4CCCCC4)N=C3)=C(F)C=C1N=C2


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