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Product Information:

AMG-176

Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM.

Cat. No.: EX-A2666    Purity: >98%
AMG-176
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
5mg1900In-stock
10mg2500In-stock
25mg4000In-stock
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SynonymsTapotoclax
Synonyms 2AMG176
CAS No.1883727-34-1
Purity>98%
FormulaC33H41ClN2O5S
Mol Weight613.207
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387.

[2]. Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142.

CoACoA of AMG-176
Smiles:[H][C@@]12CC[C@@]1([H])[C@@H](OC)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)C1=CC=C3OC[C@]4(CCCC5=CC(Cl)=CC=C45)CN(C2)C3=C1

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