CCT251545

CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with an IC50 of 5 nM in 7dF3 cells^[1]. CCT251545 is a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease^[2].


Cat. No.: EX-A2539	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	965	In-stock
250mg	1465	In-stock
500mg	2265	In-stock
1g	3550	In-stock
5g	9850	In-stock

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CAS No.	1661839-45-7
Purity	>98%
Formula	C23H24ClN5O
Mol Weight	421.923
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mallinger A, et al. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. J Med Chem. 2015 Feb 26;58(4):1717-35. [2]. Dale T, et al. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat Chem Biol. 2015 Dec;11(12):973-980.
CoA	CoA of CCT251545

Smiles:	CN1C=C(C=N1)C1=CC=C(C=C1)C1=CN=CC(Cl)=C1N1CCC2(CCNC2=O)CC1


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