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Product Information:

Abrocitinib

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively.

Cat. No.: EX-A3037    Purity: >98%
Abrocitinib
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg585In-stock
250mg885In-stock
1g1385In-stock
5g4150In-stock
10g6900In-stock


SynonymsPF-04965842
CAS No.1622902-68-4
Purity>98%
FormulaC14H21N5O2S
Mol Weight323.414
AppearanceSolid powder
SolubilitySoluble in DMSO, not in water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Vazquez ML, et al. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61(3):1130-1152.
CoACoA of Abrocitinib
Smiles:CCCS(=O)(=O)N[C@H]1C[C@H](C1)N(C)C1=C2C=CNC2=NC=N1

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