Adavivint

Adavivint (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.


Cat. No.: EX-A2711	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	685	In-stock
500mg	985	In-stock
1g	1385	In-stock
2g	2200	In-stock
5g	4365	In-stock
10g	6450	In-stock

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Synonyms	SM04690
Synonyms 2	Lorecivivint
CAS No.	1467093-03-3
Purity	>98%
Formula	C29H24FN7O
Mol Weight	505.5456
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Deshmukh V, et al. A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 2018 Jan;26(1):18-27. doi: 10.1016/j.joca.2017.08.015. Epub 2017 Sep 6. PubMed PMID: 28888902. [2]. Yazici Y, et al. A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study. Osteoarthritis Cartilage. 2017 Oct;25(10):1598-1606. doi:10.1016/j.joca.2017.07.006. Epub 2017 Jul 13. PubMed PMID: 28711582.
CoA	CoA of Adavivint

Smiles:	CC(C)CC(=O)NC1=CC(=CN=C1)C1=CC2=C(NN=C2C2=NC3=C(N2)C(=CN=C3)C2=CC=CC(F)=C2)C=C1


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