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Product Information:

CCG-203971

CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 μM. Potential anti-metastasis Agent.

Cat. No.: EX-A1813    Purity: >98%
CCG-203971
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg650In-stock
1g900In-stock
2g1600In-stock
5g3500In-stock
10g5285In-stock


CAS No.1443437-74-8
Purity>98%
FormulaC23H21ClN2O3
Mol Weight408.877
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Bell JL, et al. Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32.

[2]. Johnson LA, et al. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts. Inflamm Bowel Dis. 2014 Jan;20(1):154-65.

CoACoA of CCG-203971
Smiles:ClC1=CC=C(NC(=O)C2CCCN(C2)C(=O)C2=CC=CC(=C2)C2=CC=CO2)C=C1

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