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Product Information:

CEP-40783

RXDX-106 (CEP-40783) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/Met (c-Met) inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively.

Cat. No.: EX-A2540    Purity: >98%
CEP-40783
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg465In-stock
250mg765In-stock
1g1550In-stock
5g4650In-stock
10g6950In-stock


CAS No.1437321-24-8
Purity>98%
FormulaC31H26F2N4O6
Mol Weight588.5581
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1] Erin D. Lew, et al. RXDX-106, a novel, selective and potent small molecule TAM (TYRO3, AXL, MER) inhibitor, demonstrates efficacy in TAM-driven tumors. AACR; Cancer Res 2017, 77(13 Suppl):Abstract nr 4191.

[2]. Sheila M, et al. CEP-40783: A potent and selective AXL/c-Met inhibitor for use in breast, non-small cell lung (NSCLC), and pancreatic cancers. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C275.
CoACoA of CEP-40783
Smiles:COC1=C(OC)C=C2C(OC3=CC=C(NC(=O)C4=CN(C(C)C)C(=O)N(C4=O)C4=CC=C(F)C=C4)C=C3F)=CC=NC2=C1

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