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Product Information:

CCX168

Avacopan (CCX168) is an orally active, selective and potent C5aR inhibitor.

Cat. No.: EX-A2605    Purity: >98%
CCX168
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg400In-stock
250mg785In-stock
500mg1150In-stock
1g1550In-stock
5g4650In-stock
10g6975In-stock


SynonymsAvacopan
CAS No.1346623-17-3
Purity>98%
FormulaC33H35F4N3O2
Mol Weight581.6435
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Bekker, Pirow et al. Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study. PloS one vol. 11,10 e0164646. 21 Oct. 2016.

[1]. Xiao, Hong et al. C5a receptor (CD88) blockade protects against MPO-ANCA GN. Journal of the American Society of Nephrology : JASN vol. 25,2 (2014): 225-31.

CoACoA of CCX168
Smiles:CC1=CC=C(NC(=O)[C@H]2CCCN([C@H]2C2=CC=C(NC3CCCC3)C=C2)C(=O)C2=C(C)C=CC=C2F)C=C1C(F)(F)F

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