BML-275

Dorsomorphin (Compound C) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy.


Cat. No.: EX-A616	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	335	In-stock
250mg	485	In-stock
500mg	600	In-stock
1g	800	In-stock
5g	2465	In-stock
10g	3665	In-stock

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Synonyms	Dorsomorphin
CAS No.	866405-64-3
Purity	>98%
Formula	C24H25N5O
Mol Weight	399.4882
Appearance	solid powder
Solubility	1M HCl : 50 mg/mL (125.16 mM; ultrasonic and adjust pH to 1 with HCl) Ethanol : 3.33 mg/mL (8.34 mM; Need ultrasonic)
Shelf Life	>2 years if stored properly
Storage	4°C, protect from light -20°C, 1 month (protect from light)
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of action. J Clin Invest. 2001 Oct;108(8):1167-74. [2]. Kim YM, et al. Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo. Atherosclerosis. 2011 Nov;219(1):57-64. [3]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.
CoA	CoA of BML-275

Smiles:	C(CN1CCCCC1)OC1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=CC=NC=C1


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