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Product Information:

AMG-706 Diphosphate

Motesanib Diphosphate (AMG 706 Diphosphate) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is approximately 10-fold more selective for VEGFR than PDGFR and Ret.

Cat. No.: EX-A453    Purity: >98%
AMG-706
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg385In-stock
500mg585In-stock
1g885In-stock
2g1416In-stock
5g2655In-stock
10g4248In-stock


SynonymsMotesanib Diphosphate
Synonyms 2AMG 706 Diphosphate
CAS No.857876-30-3
Purity>98%
FormulaC22H29N5O9P2
Mol Weight569.4413
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Polverino A, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer R

[2]. Kruser TJ, et al. Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors. Clin Cancer Res, 2010, 16(14), 3639-3647.

[3]. Coxon A, et al. Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors. Clin Cancer Res, 2009, 15(1), 110-118.

CoACoA of AMG-706 Diphosphate
Smiles:OP(O)(O)=O.CC1(C)CNC2=C1C=CC(NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1)=C2

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