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Product Information:

AZD8931

Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.

Cat. No.: EX-A036    Purity: >98%
AZD8931
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1g695In-stock
5g2200In-stock


SynonymsSapitinib
Synonyms 2AZD-8931
CAS No.848942-61-0
Purity>98%
FormulaC23H25ClFN5O3
Mol Weight473.928
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Hickinson DM, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res. 2010 Feb 15;16(4):1159-69.
CoACoA of AZD8931
Smiles:CNC(=O)CN1CCC(CC1)OC1=CC2=C(NC3=CC=CC(Cl)=C3F)N=CN=C2C=C1OC

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