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Product Information:

Brivanib alaninate

Brivanib alaninate (BMS-582664) is the prodrug of BMS-540215, an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM.

Cat. No.: EX-A012    Purity: >98%
Brivanib
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg650In-stock
250mg1120In-stock
1g2320In-stock


SynonymsBMS-582664
CAS No.649735-63-7
Purity>98%
FormulaC22H24FN5O4
Mol Weight441.4555
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Bhide, Rajeev S et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. Journal of medicinal chemistry vol. 49,7 (2006): 2143-6.

[2]. Huynh, Hung et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 14,19 (2008): 6146-53.

CoACoA of Brivanib alaninate
Smiles:C[C@H](COC1=CN2N=CN=C(OC3=C(F)C4=C(NC(C)=C4)C=C3)C2=C1C)OC(=O)[C@H](C)N

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