AS601245

AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties.


Cat. No.: EX-A634	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	Get quote
100mg	485	In-stock
250mg	885	In-stock
500mg	1385	In-stock
1g	1885	In-stock
5g	4800	In-stock

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CAS No.	345987-15-7
Purity	>98%
Formula	C20H16N6S
Mol Weight	372.446
Appearance	Solid powder
Solubility	soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Carboni S, et al. AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. J Pharmacol Exp Ther. 2004;310(1):25-32.
CoA	CoA of AS601245

Smiles:	N#CC(C1=NC2=CC=CC=C2S1)C1=NC(NCCC2=CC=CN=C2)=NC=C1


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