background


Product Information:

BAR 502

BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.

Cat. No.: EX-A1734    Purity: >98%
BAR
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg500In-stock
250mg800In-stock
500mg1200In-stock
1g1800In-stock
5g4800In-stock


CAS No.1612191-86-2
Purity>98%
FormulaC25H44O3
Mol Weight392.6151
AppearanceSolid powder
SolubilitySoluble in DMF/ethanol
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Festa C, et al. Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands. J Med Chem. 2014 Oct 23;57(20):8477-95.

[2]. Carino A, et al. BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis. Sci Rep. 2017 Feb 16;7:42801.

[3]. Cipriani S, et al. Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling. PLoS One. 2015 Jul 15;10(7):e0129866.

CoACoA of BAR 502
Smiles:CCC1C(O)[C@H]2[C@@H]3CC[C@H](C(C)CCO)[C@@]3(C)CC[C@H]2[C@@]2(C)CCC(O)C[C@@H]12

KEYWORDS: buy BAR 502 | BAR 502 supplier | purchase | cost | manufacturer | order | distributor | buy 1612191-86-2 | 1612191-86-2 supplier