BI-882370

BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases.


Cat. No.: EX-A1514	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	765	In-stock
100mg	998	In-stock
250mg	1785	In-stock
500mg	2985	In-stock
1g	4600	In-stock

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CAS No.	1392429-79-6
Purity	>98%
Formula	C28H33F2N7O2S
Mol Weight	569.669
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Waizenegger IC, et al. A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation. Mol Cancer Ther. 2016 Mar;15(3):354-65. [2].Stadtmueller, Heinz,. Preparation of azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors. WO2012104388A1
CoA	CoA of BI-882370

Smiles:	CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=NC(=CC=C23)N(C)C2CCN(CC)CC2)C2=CN=CN=C2)=C1F


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