ACY738

ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50 of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM.


Cat. No.: EX-A1136	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	650	In-stock
250mg	950	In-stock
500mg	1350	In-stock
1g	1885	In-stock
5g	4785	In-stock

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Synonyms	ACY-738
CAS No.	1375465-91-0
Purity	>98%
Formula	C14H14N4O2
Mol Weight	270.2866
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jochems J, et al. Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability. Neuropsychopharmacology. 2014 Jan;39(2):389-400. [2]. Regna NL, et al. Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB/W mice. Clin Immunol. 2016 Jan;162:58-73. [3]. Mithraprabhu S, et al. Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC. Br J Haematol. 2013 Aug;162(4):559-62.
CoA	CoA of ACY738

Smiles:	ONC(=O)C1=CN=C(NC2(CC2)C2=CC=CC=C2)N=C1


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