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Product Information:

CNX-2006

CNX-2006 is a mutant-selective and irreversible EGFR inhibitor with an IC50 below 20 nM for EGFR T790M.

Cat. No.: EX-A1048    Purity: >98%
CNX-2006
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg550In-stock
250mg920In-stock
500mg1350In-stock
1g1950In-stock


CAS No.1375465-09-0
Purity>98%
FormulaC26H27F4N7O2
Mol Weight545.5319
AppearanceSolid powder
SolubilityDMSO > 50 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Galvani E, et al. Abstract 3244: Role of epithelial-mesenchymal transition (EMT) in sensitivity to CNX-2006, a novel mutant-selective EGFR inhibitor which overcomes in vitro T790M-mediated resistance in NSCLC. CNX-2006, a novel mutant-selective EGFR inhibitor which overcomes in vitro T790M-mediated resistance in NSCLC. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Ishington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3244. doi:10.1158/1538-7445.AM2013-3244
CoACoA of CNX-2006
Smiles:COC1=CC(NC2CN(CCF)C2)=CC=C1NC1=NC=C(C(NC2=CC(NC(=O)C=C)=CC=C2)=N1)C(F)(F)F

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