AZD-4635

Imaradenant (AZD4635, HTL1071) is an oral A2AR antagonist that binds to human A2AR with a Ki of 1.7 nM and with > 30-fold selectivity over other adenosine receptors.


Cat. No.: EX-A1681	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	350	In-stock
250mg	550	In-stock
500mg	750	In-stock
1g	1000	In-stock
5g	3000	In-stock
10g	4800	In-stock

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Synonyms	Imaradenant
Synonyms 2	HTL1071
CAS No.	1321514-06-0
Purity	>98%
Formula	C15H11ClFN5
Mol Weight	315.733
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jazayeri A, Andrews SP, Marshall FH. Structurally Enabled Discovery of Adenosine A(2A) Receptor Antagonists. Chem Rev. 2017 Jan 11;117(1):21-37. doi:10.1021/acs.chemrev.6b00119. Epub 2016 Jun 22. Review. PubMed PMID: 27333206. [2]. Alexandra Borodovsky, et al. Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR Cancer Res. 2017, 77(13 Suppl):Abstract nr 5580.
CoA	CoA of AZD-4635

Smiles:	CC1=CC(=CC(Cl)=N1)C1=C(N=C(N)N=N1)C1=CC=C(F)C=C1


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