Inhibitor Specialist 
Product Information:
| Cat. No.: EX-A403 | Purity: >98% |
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| Size | Unit Price (US$) | Stock | Quantity | Order |
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| Send PO to E-mail:order@excenen.com; or Fax:+86 020 81619670 |
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| Synonyms | Pimasertib |
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| CAS No. | 1236699-92-5 |
| Purity | >98% |
| Formula | C15H15FIN3O3 |
| Mol Weight | 431.2008 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Storage | Powder -20℃ 2 years; In solvent -20℃ 1 month; |
| Shipping | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Reference: | [1]. Park SJ, et al. The MEK1/2 inhibitor AS703026 circumvents resistance to the BRAF inhibitor PLX4032 in human malignant melanoma cells. Am J Med Sci. 2013 Dec;346(6):494-8.
[2]. Yoon J, et al. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res, 2011, 71(2), 445-453. [3]. Kim K, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol, 2010, 149(4), 537-549. |
| CoA | CoA of AS703026 |
| Smiles: | OC[C@@H](O)CNC(=O)C1=CC=NC=C1NC1=CC=C(I)C=C1F |
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