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Product Information:

CC-122

Avadomide (CC 122) is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity and induces apoptosis of diffuse large B-cell lymphoma (DLBCL) cell lines. Avadomide exhibits potent antitumor and immunomodulatory activities.

Cat. No.: EX-A1191    Purity: >98%
CC-122
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
200mg550In-stock
500mg700In-stock
1g950In-stock
5g2885In-stock
10g4616In-stock


SynonymsAvadomide
CAS No.1015474-32-4
Purity>98%
FormulaC14H14N4O3
Mol Weight286.286
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Rasco DW, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 Jan 1;25(1):90-98.

[2]. Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an IFN response and has antitumor activity in DLBCL.Blood.Aug 6;126(6):779-89.

CoACoA of CC-122
Smiles:CC1=NC2=C(C(N)=CC=C2)C(=O)N1C1CCC(=O)NC1=O

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