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Product Information:

BMS754807

BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases (Ki, <2 nmol/L). It is currently in phase I development for the treatment of a variety of human cancers.

Cat. No.: EX-A711    Purity: >98%
BMS754807
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg525In-stock
250mg775In-stock
1g1200In-stock
5g4500In-stock
10g6750In-stock


CAS No.1001350-96-4
Purity>98%
FormulaC23H24FN9O
Mol Weight461.4948
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1] Carboni JM, et al. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther, 2009, 8(12), 3341-3349.

[2] Wittman MD, et al. Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem, 2009, 52(23), 7360-7363.

[3] Kolb EA, et al. Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr Blood Cancer, 2011, 56(4), 595-603.
CoACoA of BMS754807
Smiles:C[C@]1(CCCN1C1=NN2C=CC=C2C(NC2=NNC(=C2)C2CC2)=N1)C(=O)NC1=CC=C(F)N=C1

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